Nematode control of livestock

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A Phenomics Australia case study

Phenomics Australia has enabled the repurposing of known drugs to control parasitic nematodes in livestock.

The challenge:

The control of gastrointestinal nematodes in livestock has relied largely on the use of a limited number of anti-parasitic drugs. However, drug resistance is now very widespread and no vaccines are available for the vast majority of these worms.

The solution:

The development of new drugs is crucial to ensure effective and sustained nematode control into the future.

The future:

The repurposing of known drugs or bioactive chemicals with known safety profiles and modes of action has the potential to proceed to clinical trials more rapidly than newly discovered chemotypes.

References:

–  Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber’s pole worm and other parasitic nematodes.

–  Screening of the ‘Stasis Box’ identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus

–  Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro

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