The Phenomics Australia Histopathology & Slide Scanning Service has just added the Sysmex XN1000-V haematology analyser to the service. This system delivers a highly comprehensive CBC and differential blood analysis.
As part of the comprehensive mouse necropsy evaluation, a complete blood count (CBC) and blood differential test is performed on terminal blood. This provides a general health status of the animal at end stage and other indicators that align with and support associated histopathology results.
Specifically tailored for veterinary applications, the XN1000-V is validated for mice and rats, bringing a new level of precision, speed, and reliability to our service.
Investing in advanced tools like the XN1000-V is part of our ongoing commitment to excellence in research.
The analyser will be available to all internal and external researchers later in the year.
We can’t wait to show you what this technology can do!
For more information on all our services, please contact Tina Cardamone at t.cardamone@unimelb.edu.au or visit their website:
Check out some of the photos from the training session on the right.
Story behind the images:
Would you like to know what these images are showing? Click on them for a precise histopathology explanation:
Blue bubbles in the subcutaneous tissue of the mouse tail …. curious!
There is a simple explanation to this intriguing histopathological finding.
This is what a blue UV ink tattoo on the mouse tail looks like under the microscope-pretty artefact.
Red blood cells come in all shapes and sizes—but sometimes, that kind of diversity spells trouble."
Here is an example of Poikilocytosis (the presence of irregularly shaped red blood cells). The underlying causes can range from anaemia to liver disease and even cancer. In this animal, all signs point to haemolytic anaemia.
The film also shows hypochromasia and polychromasia!
The image was acquired on the 3DHistech P480 Slide Scanner.
Kidney: a scoring system of Grade 0-3 is used to illustrate degrees of change. Micromorphological changes shown below include tubular damage such as tubular dilation, degeneration and necrosis, and tubular protein casts
-Grade 3-
The Phenomics Australia Histopathology and Digital Slide Service provides necropsy and histopathology services to all biomedical researchers across Australia for evaluating or phenotyping modified, treated, experimental or genetically engineered mice at all developmental stages.
A team of experienced medical, veterinary pathologists and mouse pathobiologists determine whether morphological changes or pathology identified are strain-related, age-related, incidental or a true diversion from normal. The mouse strains are therefore validated and utilised as models of human disease.
The Histopathology and Digital Slide Service is based at the Department of Anatomy and Physiology at the University of Melbourne and is supported by the Federal Government through the National Collaborative Research Infrastructure Strategy (NCRIS) initiative and by the University of Melbourne.
